The "100-100-100" initiative, launched by the Directorate of Public Health and Preventive Medicine, stands as an ambitious effort to cultivate a research culture and harness existing data resources within the health system for informed policy decisions. This article explores the inception, execution, and challenges encountered during the implementation of the initiative. The outcome revealed that 50% of the submitted proposals were completed, with 4.8% published or under review and 45.1% presented at a workshop organized by the Directorate. The "100-100-100" initiative represents a significant leap in promoting research and evidence-based decision-making in public health.