This article explores the strategies, challenges, and progress towards rabies elimination, focusing on Tamil Nadu. Despite a decline in rabies-related deaths, achieving the goal of zero deaths remains challenging. Strategies include ensuring timely post-exposure prophylaxis for humans, emphasizing vaccine availability and healthcare professional training. The animal component involves mass canine vaccination and birth control, with challenges in estimating stray dog populations and implementing systematic vaccination. Legislative frameworks related to rabies control are presented, emphasizing a One Health approach. Successful models from states like Goa and Sikkim illustrate the feasibility of elimination. The environmental component stresses effective solid waste management to reduce human-dog conflicts. This holistic approach, involving collaboration and urgency, is crucial for successfully combating rabies in Tamil Nadu.