BACKGROUND : Chronic Kidney Disease (CKD) and Chronic Kidney Disease of Unknown Etiology (CKDu) are in the rising trend in Tamil Nadu especially in rural regions. It not only burdens on the mortality rate but also affects the quality of life of the people. At least Rs 1 of every Rs 10 claimed under the Tamil Nadu Chief Minister Health Insurance Scheme goes for Hemodialysis. . There is a wide knowledge gap in the disease’s trend, distribution and other parameters affecting the course of the disease. CKDu is found to have multifactorial etiologies and is prevalent only in certain pockets all over the state. Our regular screening tools could not identify these patients early; hence they seek medical care only during the terminal stages of the disease.Formulating active screening for kidney injury and maintaining a CKD database will help us in the early identification and treatment of the disease. It will also help in identifying CKD Hotspots, which will help in a better understanding of the disease and may even help to formulate a scoring system using the risk factors for CKDu and subsequently design prevention strategies for the disease in a cost-effective manner.