BACKGROUND : The goal of public health is eradication and elimination of diseases. Tamil Nadu aims at eliminating 7 diseases namely leprosy, lymphatic filariasis, tuberculosis, malaria, dog mediated rabies, measles, rubella by the year 2025. This article would focus on the status of leprosy in Tamil Nadu and the interventions that are adopted towards eliminating these diseases. Tamil Nadu aims at achieving elimination of leprosy with 90% reduction of new Child cases and 90% reduction of new Grade II deformity cases by the year 2030. Districts are categorized and prioritized based on Annual new case detection rate and grade 2 deformity. District wise leprosy status and the interventions carried out are elaborated in this article. Close monitoring will lead to elimination status in Tamil Nadu.